Pharmacokinetic (Bioavailability) Studies of Magnesium Preparations
نویسندگان
چکیده
In order to obtain valid results when studying the bioavailability of medicinal products containing magnesium salts, it is necessary take into account endogenous levels macroelement in body. The aim study was conduct a systematic review clinical studies on magnesium, evaluate methods used for determining level and establish necessity adjusting pharmacokinetic parameters according identified levels. includes data from performed with healthy volunteers published over past 5 years. According literature results, most commonly chosen primary endpoint urinary excretion analysis, secondary plasma or serum determination. Data sources included Google’s search engine; PubMed, UpTodate®, ClinicalTrials.gov databases; official websites regulatory authorities (EFSA, EMA, FDA). studies, were taken at all blood sampling points, this provided an opportunity avoid errors misinterpretations results. Adjustments regard values differently. Some treated as independent variables compared obtained after drug administration them; other covariate influencing requiring mandatory consideration; two involved classical adjustment parameters, subtraction administration. evaluation part adjust It should be planned beforehand time preparation protocol.
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ژورنال
عنوان ژورنال: Vedomosti Nau?nogo centra èkspertizy sredstv medicinskogo primeneniâ
سال: 2022
ISSN: ['1991-2919', '2619-1172']
DOI: https://doi.org/10.30895/1991-2919-2022-419